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Diethylstilbestrol

Cayman Chemical Item Number 10006876

(CAS 56-53-1)

Diethylstilbestrol (CAS 56-53-1)

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Description

Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring.1 DES is structurally related to, and is as potent as, estradiol in most assays, with a longer half-life. It has a relative binding affinity to sex hormone binding globulin (SHBG) of 0.2 compared to estradiol which has a relative binding affinity of 100. A concentration of 20 µM DES, displaces 30 ± 13% of 3H-estradiol from SHBG in serum.1,2

1 Coelingh Bennink, H.J.T. Are all estrogens the same? Maturitas 47 269-275 (2003).

2 Jury, H.H., Zaxharewski, T.R., and Hammond, G.L. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol 75 167-176 (2000).

Formal Name 4,​4'[(1E)-​1,​2-​diethyl-​1,​2-​ethenediyl]bis-​phenol
CAS Number 56-53-1
Molecular Formula C18H20O2
Formula Weight 268.4
Formulation A crystalline solid
Purity ≥98%
λmax 240 nm
Stability 2 months
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC\C(=C(\CC)​/c1ccc(O)​cc1)​\c1ccc(O)​cc1

Background Reading

Coelingh Bennink, H.J.T. Are all estrogens the same? Maturitas 47 269-275 (2003).

Jury, H.H., Zaxharewski, T.R., and Hammond, G.L. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol 75 167-176 (2000).

Diethylstilbestrol is available in the following screening library:

Size Price Quantity Subtotal
1 g $20.00 $0.00
5 g $90.00 $0.00
10 g $160.00 $0.00
25 g $350.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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