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Combrestatin A4

Cayman Chemical Item Number 10007412

CRC 87-09; Combretastatin A4; CA4 (CAS 117048-59-6)

Combrestatin A4 (CAS 117048-59-6)

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Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. CA4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively.1 CA4 inhibits tubulin polymerization with an IC50 value of 2.2 µM.2

1 Sun, L., Vasilevich, N.I., Fuselier, J.A., et al. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res 24 179-186 (2004).

2 Dey, P. Chromatin remodeling, cancer and chemotherapy. Curr Med Chem 13 2909-2919 (2006).

Synonyms
  • CRC 87-09
  • Combretastatin A4
  • CA4
Formal Name 2-​methoxy-​5-​[(1Z)-​2-​(3,​4,​5-​trimethoxyphenyl)ethenyl]-​phenol
CAS Number 117048-59-6
Molecular Formula C18H20O5
Formula Weight 316.4
Formulation A crystalline solid
Purity ≥98%
λmax 222, 296 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1cc(\C=C\c2ccc(OC)​c(O)​c2)​cc(OC)​c1OC

Background Reading

Dey, P. Chromatin remodeling, cancer and chemotherapy. Curr Med Chem 13 2909-2919 (2006).

Sun, L., Vasilevich, N.I., Fuselier, J.A., et al. Abilities of 3,4-diarylfuran-2-one analogs of combretastatin A-4 to inhibit both proliferation of tumor cell lines and growth of relevant tumors in nude mice. Anticancer Res 24 179-186 (2004).

Combrestatin A4 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $50.00 $0.00
10 mg $95.00 $0.00
25 mg $225.00 $0.00
50 mg $400.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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