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Pargyline (hydrochloride)

Cayman Chemical Item Number 10007852

(CAS 306-07-0)

Pargyline (hydrochloride) (CAS 306-07-0)

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Description

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.1,2 At 10 mg/kg iv, pargyline induces a moderate decrease of systolic blood pressure in unanaesthetized hypertensive rats but not normotensive WKR or Sprague-Daley rats.3 The correlation between the fall of blood pressure and the inhibition of brain MAO suggests that the accumulation of amine in brain is responsible for the fall in pressure.4 Reactive oxygen species-mediated monocyte hypertrophy is prevented by pargyline at a concentration of 10 µM.1

1 Bianchi, P., Pimentel, D.R., Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation. FASEB J 1-15 (2005).

2 Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. J Pharmacol Exp Ther 182(1) 130-134 (1972).

3 Fuentes, J.A., Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. Eur J Pharmacol 57 21-27 (1979).

4 Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. J Pharm Pharmacol 24 690-695 (1972).

Formal Name N-​methyl-​N-​2-​propynyl-​benzenemethanamine,​ monohydrochloride
CAS Number 306-07-0
Molecular Formula C11H13N · HCl
Formula Weight 195.7
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CN(CC#C)​CC1=CC=CC=C1.Cl

Background Reading

Bianchi, P., Pimentel, D.R., Murphy, M.P., et al. A new hypertrophic mechanism of serotonin in cardiac myocytes: Receptor-independent ROS generation. FASEB J 1-15 (2005).

Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. J Pharm Pharmacol 24 690-695 (1972).

Fuentes, J.A., Ordaz, A., and Neff, N.H. Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats. Eur J Pharmacol 57 21-27 (1979).

Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. J Pharmacol Exp Ther 182(1) 130-134 (1972).

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Pargyline (hydrochloride) is available in the following screening library:

Size Price Quantity Subtotal
100 mg $6.00 $0.00
500 mg $27.00 $0.00
1 g $48.00 $0.00
5 g $210.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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