A derivative of curcurmin with anti-inflammatory and antioxidant activities
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Isomer(s)
10008187Dimethylcurcumin
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Dimethoxycurcumin

Item No. 10009986

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,7-bis(3,4-dimethoxyphenyl)-1,6-heptadiene-3,5-dione
CAS Number
160096-59-3
Synonyms
  • Di-O-methylcurcumin
Molecular Formula
C23H24O6
Formula Weight
396.4
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:2): 0.30 mg/mlDMSO: 5 mg/mlEthanol: 0.25 mg/ml
λmax
418 nm
SMILES
COC1=C(OC)C=C(/C=C/C(CC(/C=C/C2=CC=C(OC)C(OC)=C2)=O)=O)C=C1
InChi Code
InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-14H,15H2,1-4H3/b9-5+,10-6+
InChi Key
HMJSBVCDPKODEX-NXZHAISVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Dimethoxycurcumin is a derivative of curcumin (Item No. 81025) that has anti-inflammatory and antioxidant activities.1,2,3 It inhibits mitogen-induced proliferation of CD4+ T cells, CD8+ T cells, and B cells, as well as secretion of IL-2, IL-4, IL-6, and IFN-γ induced by concanavalin A (Item No. 14951) in isolated human lymphocytes when used at concentrations ranging from 1 to 10 µM.1 Dimethoxycurcumin (1-10 µM) inhibits LPS-induced nitric oxide (NO) production and expression of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells.2 It inhibits hemolysis of isolated human red blood cells (RBCs) induced by AAPH (Item No. 82235) when used at a concentration of 10 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patwardhan, R.S., Checker, R., Sharma, D., et al. Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes. Biochem. Pharmacol. 82(6), 642-657 (2011).

    2. Pae, H.-O., Jeong, S.-O., Kim, H.S., et al. Dimethoxycurcumin, a synthetic curcumin analogue with higher metabolic stability, inhibits NO production, inducible NO synthase expression and NF-κB activation in RAW264.7 macrophages activated with LPS. Mol. Nutr. Food Res. 52(9), 1082-1091 (2008).

    3. Deng, S.-L., Chen, W.-F., Zhou, B., et al. Protective effects of curcumin and its analogues against free radical-induced oxidative haemolysis of human red blood cells. Food Chem. 98(1), 112-119 (2006).