Cayman Chemical | AICAR | Description • NSC 105823; Acadesine; AICA Riboside (CAS 2627-69-2)

10010241 AICAR

NSC 105823; Acadesine; AICA Riboside (CAS 2627-69-2)

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AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.¹ AICAR is a selective activator of AMPK in both hepatocytes and adipocytes.² At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.² AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes.³ It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.⁴

1 Hardie, D.G., Carling, D. The AMP-activated protein kinase. Fuel gauge of the mammalian cell?. Eur J Biochem 246 259-273 (1997).

2 Corton, J.M., Gillespie, J.G., Hawley, S.A., et al. 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?. Eur J Biochem 229 558-565 (1995).

3 Salt, I.P., Connell, J.M.C., Gould, G.W. 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes 49 1649-1656 (2000).

4 Ayasolla, K.R., Giri, S., Singh, A.K., et al. 5-aminoimidazole-4-carboxamide-I-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia. Journal of Neuroinflammation 2 1-21 (2005).

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Pricing updated 2010-03-12.
Prices are subject to change without notice.