|
10137 Icilin
AG 3-5
(CAS 36945-98-9)
Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
|
Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin (AG 3-5) is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol.1 Icilin induces sensations of intense cold when applied orally in humans, and induces 'wet dog shakes', a behavioral marker of cold sensation, when given to rats. Icilin should serve as the reference cold nociceptive agonist for TRP-type ion channels in the future.2
|
|
1
McKemy, D.D., Neuhausser, W.M., Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52-58 (2002).
2
Wei, E.T., Seid, D.A. AG-3-5: A chemical producing sensations of cold. J Pharm Pharmacol 35 110-112 (1983).
|
Purchase 10137 Icilin
Pricing is for North America only. Other customers should contact a distributor in their region.
This product is also available to buy in bulk quantities.
Please contact our
Sales Department
for a quote or to purchase.
Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services.
To ask for assistance with one of our products please contact our Technical Help staff.
Warning This product is not for human or veterinary use.
|
Pricing updated 2009-07-04.
Prices are subject to change without notice.
|
|
|
|
|
