β-oxidation product found in urine of healthy humans
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2,3-dinor-6-keto Prostaglandin F1α (sodium salt)

Item No. 15120

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-oxo-9α,11α,15S-trihydroxy-2,3-dinor-prost-13E-en-1-oic acid, monosodium salt
Synonyms
  • 2,3-dinor-6-keto PGF1α
Molecular Formula
C18H29O6 • Na
Formula Weight
364.4
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlMethanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@@H]1[C@H](CC(CCC([O-])=O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1.[Na+]
InChi Code
InChI=1S/C18H30O6.Na/c1-2-3-4-5-12(19)6-8-14-15(17(22)11-16(14)21)10-13(20)7-9-18(23)24;/h6,8,12,14-17,19,21-22H,2-5,7,9-11H2,1H3,(H,23,24);/q;+1/p-1/b8-6+;/t12-,14+,15+,16+,17-;/m0./s1
InChi Key
CXELZMXZXOSIRU-DBAZFWCESA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    2,3-dinor-6-keto prostaglandin F1α (2,3-dinor-6-keto PGF1α) is the β-oxidation product of 6-keto PGF1α and the major urinary metabolite of PGI2 in humans.1,2 2,3-dinor-6-keto PGF1α makes up 23% of the recovered radioactivity in urine after administration of labeled 6-keto PGF1α and 20.5% after administration of labeled PGI2.2 In healthy human subjects, the average excreted 2,3-dinor-6-keto PGF1α level is ~100 pg/mg creatinine.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv. Prostaglandin Thromboxane Leukot. Res. 15, 87-90 (1985).

    2. Rosenkranz, B., Fischer, C., Reimann, I., et al. Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F1α in man. Biochim. Biophys. Acta 619(2), 207-213 (1980).

    3. Wennmalm, Å., Benthin, G., Granström, E.F., et al. 2,3-Dinor metabolites of thromboxane A2 and prostacyclin in urine from healthy human subjects: Diurnal variation and relation to 24h excretion. Clin. Sci. (Lond.) 83(4), 461-465 (1992).

    Product Citations

    Sasaki, A., Fukuda, H., Shiida, N., et al. Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS. Anal. Bioanal. Chem. 407(6), 1625-1639 (2015).