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D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)

Cayman Chemical Item Number 60980

Ins(1,3,4,5)-P₄ (sodium salt); 1,3,4,5-IP₄ (sodium salt) (CAS 210488-61-2)

D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) (CAS 210488-61-2)

See more	Inositol Phosphates (78) Lipids (167) Signal Transduction (314)

Description

D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P₄) is formed by the phosphorylation of Ins(1,4,5)P₄ by inositol 1,4,5-triphosphate 3-kinase.^1,2 Ins(1,3,4,5)-P₄ increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell.³

1 Billington, D.C., Baker, R., Kulagowski, J.J., et al. Synthesis of myo-inositol 1-phosphate and 4-phosphate, and their individual enantiomers. J Chem Soc Chem Commun 314-316 (1987).

2 Communi, D., Vanweyenberg, V., and Erneux, C. Purification and biochemical properties of a high-molecular-mass inositol 1,4,5-trisphosphate 3-kinase isoenzyme in human platelets. Biochem J 298 669-673 (1994).

3 Lückhoff, A., and Clapham, D.E. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel. Nature 355 356-358 (1992).

Synonyms	Ins(1,3,4,5)-P4 (sodium salt) 1,3,4,5-IP4 (sodium salt)
Formal Name	D-myo-inositol-1,3,4,5-tetrakis(dihydrogen phosphate), octasodium salt
CAS Number	210488-61-2
Molecular Formula	C₆H₁₂O₁₈P₄ · 8Na
Formula Weight	680.0
Formulation	A lyophilized powder
Purity	≥98%
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O[C@H]1[C@@H](OP([O-])([O-])=O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1OP([O-])([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Background Reading

Billington, D.C., Baker, R., Kulagowski, J.J., et al. Synthesis of myo-inositol 1-phosphate and 4-phosphate, and their individual enantiomers. J Chem Soc Chem Commun 314-316 (1987).

Lückhoff, A., and Clapham, D.E. Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel. Nature 355 356-358 (1992).

Communi, D., Vanweyenberg, V., and Erneux, C. Purification and biochemical properties of a high-molecular-mass inositol 1,4,5-trisphosphate 3-kinase isoenzyme in human platelets. Biochem J 298 669-673 (1994).

D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt) is available in the following screening library:

Bio-active Lipid II Screening Library (96-Well)

Size	Price	Quantity	Subtotal
100 µg	$54.00		$0.00
500 µg	$225.00		$0.00
1 mg	$399.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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