NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC₅₀ value of 5-7 µM.¹ The IC₅₀ values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.^1,2

1 Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

2 Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

Pavani, M., Fones, E., Oksenberg, D., et al. Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid. Biochem Pharmacol 48 1935-1942 (1994).

Tanaka, N., Espey, L.L., Kawano, T., et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol 260, E170-E174 (1991).

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Nordihydroguaiaretic Acid is available in the following screening library:

• Bio-active Lipid I Screening Library (96-Well)