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70300 Nordihydroguaiaretic Acid
NDGA
(CAS 500-38-9)
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NDGA is a non-selective lipoxygenase inhibitor which blocks cysteinyl-leukotriene (CysLT) synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM.1 The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.1,2
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1
Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).
2
Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).
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Pricing updated 2008-10-11.
Prices are subject to change without notice.
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