Nordihydroguaiaretic Acid
Cayman Chemical Item Number 70300
NDGA
(CAS 500-38-9)
Nordihydroguaiaretic Acid
(CAS 500-38-9)
| Synonyms |
|
| Formal Name |
4,4'-(2,3-dimethyl-1,4-butanediyl)bis-1,2-benzenediol |
| CAS Number |
500-38-9 |
| Molecular Formula |
C18H22O4 |
| Formula Weight |
302.4 |
| Formulation |
A crystalline solid |
| Purity |
>95% |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
WET ICE
in continental US; may vary elsewhere
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| SMILES |
CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
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Description
NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM.1 The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.1,2
1
Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).
2
Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).
Related Articles
Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).
Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).
Pavani, M., Fones, E., Oksenberg, D., et al. Inhibition of tumoral cell respiration and growth by nordihydroguaiaretic acid. Biochem Pharmacol 48 1935-1942 (1994).
Tanaka, N., Espey, L.L., Kawano, T., et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol 260, E170-E174 (1991).
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Nordihydroguaiaretic Acid is available in the following screening
library:
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Pricing updated 2010-09-09.
Prices are subject to change without notice.
Pricing is for North America only. Other customers should contact a distributor in their region.
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Warning This product is not for human or veterinary use.
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