Cayman Chemical | Nordihydroguaiaretic Acid | Description • NDGA (CAS 500-38-9)

Holiday Notification: Cayman Chemical will be closed Friday, July 3, 2009, in observance of the 4th of July holiday. Click for details.

70300 Nordihydroguaiaretic Acid

NDGA (CAS 500-38-9)

Click image to enlarge

• See below for pricing and ordering

• See more Cyclooxygenase; Inhibitors; Lipoxygenase

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A23187-induced CysLT biosynthesis in rat peritoneal cells with an IC₅₀ value of 5-7 µM.¹ The IC₅₀ values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.^1,2

1 Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

2 Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

	Download Product Insert 108 Kb PDF
	Download Material Safety Data Sheet (MSDS) 66 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 70300 Nordihydroguaiaretic Acid

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2009-07-03.
Prices are subject to change without notice.