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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Hyperforin

Cayman Chemical Item Number 75650

(CAS 11079-53-1)

Hyperforin (CAS 11079-53-1)

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Description

St. John’s wort is a widely consumed herbal preparation which has been claimed to have a number of medicinal properties. It contains a number of known lipid signalling mediators, including chlorogenic acid, hypericin, hyperforin, and I3,II8-biapigenin. Hyperforin exhibits two activities which may alter the action of other concurrent medications. It inhibits the activity of several CYP450 enzymes, with CYP2D6 being the most sensitive with an IC50 of about 10 µg/ml.1 Hyperforin is also a ligand for the steroid X receptor (SXR).2 Since one activity of this receptor is the induction of CYP450 expression, the exact nature of hyperforin’s drug-drug interactions must be evaluated on a case-by-case basis. However, these interactions certainly complicate its use as a human therapeutic.

1 Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294(1) 88-95 (2000).

2 Wentworth, J.M., Agostini, M., Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 166 R11-R16 (2000).

Formal Name 5-​hydroxy-​6R-​methyl-​1R,​3,​7S-​tris(3-​methyl-​2-​butenyl)-​5S-​(2-​methyl-​1-​oxopropyl)-​6R-​(4-​methyl-​3-​pentenyl)-​bicyclo[3.3.1]non-​3-​ene-​2,​9-​dione
CAS Number 11079-53-1
Molecular Formula C35H52O4
Formula Weight 536.8
Formulation A solution in methanol
Purity ≥90%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CC(=CCC[C@]​1(C)​[C@@H]​(CC=C(C)​C)​CC2C(=O)​C(=C(O)​C1(C(=O)​C(C)​C)​C2=O)​CC=C(C)​C)​C

Background Reading

Chatterjee, S.S., Bhattacharya, S.K., Wonnemann, M., et al. Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci 63 499-510 (1998).

Wentworth, J.M., Agostini, M., Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. J Endocrinol 166 R11-R16 (2000).

Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther 294(1) 88-95 (2000).
Size Price Quantity Subtotal
25 µg $21.00 $0.00
50 µg $40.00 $0.00
100 µg $76.00 $0.00
1 mg $588.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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