A specific inhibitor of STAT3 signal transduction
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Galiellalactone

Item No. 15387

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7bS)-5,5aR,6,7,7aR,7b-hexahydro-7b-hydroxy-4S-methyl-indeno[1,7-bc]furan-2(4H)-one
CAS Number
133613-71-5
Molecular Formula
C11H14O3
Formula Weight
194.2
Purity
≥95%
Formulation
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
C[C@@H]1C=C2[C@@]([C@]3([H])OC2=O)(O)[C@@](CC3)([H])C1
InChi Code
InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m0/s1
InChi Key
SOIISBQQYAGDKM-QJSROADHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $409

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    5 mg

    $1,327

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    Cayman Chemical
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    Product Description

    Galiellalactone is a fungal metabolite isolated from the ascomycetes G. rufa strain A75-86 and A111-95 that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells with an IC50 value of 0.25-0.5 μM.1 The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor.1 At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Weidler, M., Rether, J., Anke, T., et al. Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 484(1), 1-6 (2000).

    2. Hellsten, R., Johansson, M., Dahlman, A., et al. Galiellalactone inhibits stem cell-like ALDH-positive prostate cancer cells. PLoS One 6(7), e221188 (2011).