A natural flavonoid
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Galangin

Item No. 15948

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one
CAS Number
548-83-4
Synonyms
  • NSC 407229
  • 3,5,7-Trihydroxyflavone
Molecular Formula
C15H10O5
Formula Weight
270.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
267, 302, 348, 361 nm
SMILES
OC1=C(C2=CC=CC=C2)OC3=CC(O)=CC(O)=C3C1=O
InChi Code
InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H
InChi Key
VCCRNZQBSJXYJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $85

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    25 mg

    $132

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    Cayman Chemical
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    Product Description

    Galangin is a flavonoid naturally found in herbs used in traditional medicine. Like many flavonoids, it has potent antioxidant properties.1 It also has anti-inflammatory actions related to suppression of signaling through NF-κB in mice.2 Galangin acts as an antagonist of the aryl hydrocarbon receptor, inducing apoptosis in cancer cells.3,4,5 It also inhibits cytochrome P450 isoform 1A1 with an IC50 value of less than 1 µM.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Duthie, G., and Morrice, P. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid. Med. Cell. Longev. 2012, 1-7 (2012).

    2. Zha, W.J., Qian, Y., Shen, Y., et al. Galangin abrogates ovalbumin-induced airway inflammation via negative regulation of NF-κB. Evid. Based Complementary Altern. Med. 2013, 1-15 (2013).

    3. Quadri, S.A., Qadri, A.N., Hahn, M.E., et al. The bioflavonoid galangin blocks aryl hydrocarbon receptor activation and polycyclic aromatic hydrocarbon-induced pre-B cell apoptosis. Mol. Pharmacol. 58(3), 515-525 (2000).

    4. Zhang, W., Lan, Y., Huang, Q., et al. Galangin induces B16F10 melanoma cell apoptosis via mitochondrial pathway and sustained activation of p38 MAPK. Cytotechnology 65(3), 447-455 (2013).

    5. Forbes, A.M., Lin, H., Meadows, G.G., et al. Synthesis and anticancer activity of new flavonoid analogs and inconsistencies in assays related to proliferation and viability measurements. Int. J. Oncol. 45(2), 831-842 (2014).

    6. Ciolino, H.P., and Yeh, G.C. The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. Br. J. Cancer 79(9-10), 1340-1346 (1999).