(+)-Evodiamine

Evodiamine is a natural indole alkaloid found in the fruits of Wu Zhu Yu, a plant used in traditional Chinese medicine. Studies involving evodiamine have demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions.^1,2,3 It can act as an aryl hydrocarbon antagonist (K_i = 28 nM), activator of the transient receptor potential vanilloid 1 channel (EC₅₀ = 45 nM), and inhibit signaling through NF-κB.^1,4,5

WARNING This product is not for human or veterinary use.

1. Yu, H., Gong, W., Wang, Z., et al. Pharmacological actions of multi-target-directed evodiamine. Molecules 18(2), 1826-1843 (2013).

2. Wang, T., Wang, X., and Yamashita, H. Evodiamine inhibits adipogenesis via the EGFR-PKCα-ERK signaling pathway. FEBS Lett. 583(22), 3655-3659 (2009).

3. Ogasawara, M., Matsubara, T., and Suzuki, H. Screening of natural compounds for inhibitory activity on colon cancer cell migration. Biol. Pharm. Bull. 24(6), 720-723 (2001).

4. Pearce, L.V., Petukhov, P.A., Szabo, T., et al. Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Org. Biomol. Chem. 2, 2281-2286 (2004).

5. Takada, Y., Kobayashi, Y., and Aggarwal, B.B. Evodiamine abolishes constitutive and inducible NF-κB activation by inhibiting IκBα kinase activation, thereby suppressing NF-κB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion. The Journal of Biological Chemisty 280(17), 17203-17212 (2005).