A disintegrin and metalloproteinase with thrombospondin motifs 5 inhibitor
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ADAMTS-5 Inhibitor

Item No. 17188

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[5-[[(4-chlorophenyl)methyl]thio]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene]-2-thioxo-4-thiazolidinone
CAS Number
929634-33-3
Molecular Formula
C16H11ClF3N3OS3
Formula Weight
449.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 20 mg/ml
λmax
225, 280, 363 nm
SMILES
ClC1=CC=C(CSC2=C(/C=C3C(NC(S/3)=S)=O)C(C(F)(F)F)=NN2C)C=C1
InChi Code
InChI=1S/C16H11ClF3N3OS3/c1-23-14(26-7-8-2-4-9(17)5-3-8)10(12(22-23)16(18,19)20)6-11-13(24)21-15(25)27-11/h2-6H,7H2,1H3,(H,21,24,25)/b11-6-
InChi Key
CVYPRDPBCXSVBN-WDZFZDKYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $63

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    1 mg

    $98

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    5 mg

    $363

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    Product Description

    ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bursavich, M.G., Gilbert, A.M., Lombardi, S., et al. Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorg. Med. Chem. Lett. 17(5), 1185-1188 (2007).

    2. Gilbert, A.M., Bursavich, M.G., Lombardi, S., et al. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg. Med. Chem. Lett. 17(5), 1189-1192 (2007).