An inactive analog of U-73122
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U-73343

Item No. 17339

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[6-[[(17b)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
CAS Number
142878-12-4
Molecular Formula
C29H42N2O3
Formula Weight
466.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.5 mg/mlEthanol: 0.25 mg/ml
SMILES
COC1=CC=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)=C1
InChi Code
InChI=1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
InChi Key
CJHWFIUASFBCKN-ZRJUGLEFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    U-73122 (Item No. 70740) is an inhibitor of PLC-dependent processes, however, the mechanism of action remains unclear.1,2,3 The IC50 values for inhibition of platelet aggregation induced by collagen or thrombin are 0.6 and 5 µM, respectively.2 It also exhibits inhibitory activity against HIV-1 integrase with an IC50 value of 7 µM.4 U-73343 is a close structural analog of U-73122 that does not inhibit PLC, making it useful as a negative control for PLC inhibition.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, R.J., Sam, L.M., Justen, J.M., et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: Effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J. Pharmacol. Exp. Ther. 253(2), 688-697 (1990).

    2. Bleasdale, J.E., Thakur, N.R., Gremban, R.S., et al. Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J. Pharmacol. Exp. Ther. 255(2), 756-768 (1990).

    3. Hildebrandt, J.P., Plant, T.D., and Meves, H. The effects of bradykinin on K+ currents in NG108-15 cells treated with U73122, a phospholipase C inhibitor, or neomycin. Br. J. Pharmacol. 120(5), 841-850 (1997).

    4. Burke, T.R., Jr., Fesen, M.R., Mazumder, A., et al. Hydroxylated aromatic inhibitors of HIV-1 integrase. J. Med. Chem. 38(21), 4171-4178 (1995).