A spin trap for nitric oxide
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PTIO

Item No. 14982

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dihydro-4,4,5,5-tetramethyl-2-phenyl-1H-imidazol-1-yloxy, 3-oxide
CAS Number
18390-00-6
Synonyms
  • α-Phenyltetramethylnitronyl nitroxide
Molecular Formula
C13H17N2O2
Formula Weight
233.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
237, 264, 348, 360, 597 nm
SMILES
[O-][N+](C(C)(C)C(C)(C)N1[O])=C1C2=CC=CC=C2
InChi Code
InChI=1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3
InChi Key
DYUUGILMVYJEHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $41

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    50 mg

    $75

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    100 mg

    $142

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    250 mg

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    Product Description

    PTIO is an oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides.1 It can be used to assay nitric oxide production when examining nitric oxide synthase inhibitory activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldstein, S., Russo, A., and Samuni, A. Reactions of PTIO and carboxy-PTIO with NO, NO2, and O 2. The Journal of Biological Chemisty 278(51), 50949-50955 (2013).

    2. Nakatsubo, N., Kojima, H., Sakurai, K., et al. Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors. Biol. Pharm. Bull. 21, 1247-1250 (1998).