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Lysophospholipids (LPA, LysoPS, LPI, S1P) transduce signals through their specific GPCRs, which activate heterotrimeric G proteins to initiate downstream signaling cascades. They have been implicated in both physiological and pathophysiological processes: autoimmune diseases, neurodegenerative diseases, fibrosis, pain, cancer, inflammation, metabolic syndrome, bone formation, fertility, development, and other effects on most organ systems. Use this wall poster to study their synthesis and signaling processes.
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