Benzodiazepines were discovered in the 1950s and were rapidly adopted as prescription medicines for the treatment of a variety of conditions, such as anxiety or use as sedatives. However, the increase in popularity of benzodiazepines, along with their addictive properties, also led to an increase in the misuse and abuse of these compounds. 

Novel designer benzodiazepines (DBZD) and novel synthetic opioids (NSO) continue to emerge on the illicit novel psychoactive substance (NPS) market. Given this trend, and the continuing rise in benzodiazepine prescriptions, the likelihood for benzodiazepines to appear in toxicological samples alongside synthetic opioids is high. Understanding the synthesis and analytical interpretation of both NPS classes can help prepare forensic toxicologists for the appearance of unknown compounds in their casework.

​Perfringolysin O (PFO^C459A) treatment permeabilizes the outer membrane of live cells, allowing for the investigation of biochemical reactions in whole cells with intact intracellular compartments, including mitochondria.

To cite this technical brief: Foss, M. and Assar, Z. Outer membrane permeabilization via perfringolysin O treatment. Technical Brief, Cayman Chemical Company (2026).

​Apolipoproteins are a diverse class of lipid-binding proteins that regulate lipid transport, metabolism, and cellular signaling. Major families, including ApoA, ApoB, ApoC, ApoD, ApoE, ApoH, ApoJ (clusterin), ApoL, and ApoM, serve as structural components of lipoproteins and modulators of lipid-associated pathways. Apolipoprotein E (ApoE) is critically involved in the pathogenesis of Alzheimer’s disease and exists in three major isoforms (ApoE2, ApoE3, and ApoE4) which differentially influence the disease risk and progression. ApoE3 exhibits relatively stable lipid interactions and supports more effective amyloid clearance compared to pathogenic isoforms, thereby reducing neurotoxicity. Since ApoE3 drives receptor-mediated interactions, ApoE3:POPC:cholesterol nanoparticles provide a physiologically relevant and tunable platform to study receptor-mediated lipid efflux and cellular lipid trafficking. Here we demonstrate how ApoE3-POPC and ApoE3-POPC-Cholesterol nanoparticles enhance the efflux of fluorescently tagged saturated fatty acids and cholesterol.

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To cite this poster: Khatri, Y., Bae, J.-Y., Anders, A., et al. ApoE3 Lipid Particles: Assembly, Dynamics, and Biological Roles. Poster presented at: 2026 Lipids@Wayne Research Symposium; May 5 – 6, 2026; Detroit, MI.

Cell and gene therapies offer transformative potential by targeting the cellular or genetic drivers of disease. Ancillary materials play a critical role in ensuring the safety and quality of the finished therapies, even though they are not intended to be part of the final product. Cayman provides two small‑molecule quality ranges: Ancillary Material and GMP Ancillary Material grades. These products meet the expectations outlined in USP <1043> Ancillary Materials for Cell, Gene, and Tissue‑Engineered Products and support consistent, reliable workflows as your programs advance from development to clinical and commercial stages.

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Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. It is an atypical opioid that is typically consumed as a part of kratom for its pain-relieving and euphoric effects and has also been researched for its use to potentially manage symptoms of opioid withdrawal and as a treatment for alcohol use disorder (AUD). More recently, analogs of mitragynine have begun to appear in the unregulated consumer marketplace and some are readily available in gas stations and vape shops in products branded as "7-hydroxymitragynine" or "7OH" causing heightened concern due to studies showing that 7-hydroxy mitragynine and mitragynine pseudoindoxyl (the rearrangement product of 7-hydroxy mitragynine) are more potent opioid agonists, exceeding that of mitragynine on the order of 10x and 100x, respectively.

Listen as Nathan Layle and Camille Waston-Gooden, synthetic chemists at Cayman Chemical, explain more about the history, pharmacology, metabolism, semi-synthetic modifications, and new emerging analogs of Mitragynine.

Presented as part of the CFSRE's 2026 Current Trends in Seized Drug Analysis Symposium.

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​We evaluated the accuracy of lipid quantitation in human plasma by LC-MS using single-point or multipoint calibration curves with authentic or surrogate standards.

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​Key Features

To cite this application note: Kwiatkowski, M.J., Goodwin, S.K., DeLoy, S.L., et al. Characterization of human plasma as a reference material for lipid analysis using LC-MS. Application Note, Cayman Chemical Company (2025).