Literature & Media

Use of a Novel Method of Derivatization to Improve LC-MS/MS Sensitivity of 1,3-Dienes

Application notes

Key Information

  • Analysis of dienes often requires increased sensitivity via derivatization reagents or sensitive analytical equipment.
  • LC-MS/MS sensitivity of the 1,3-diene vitamin D3 was tested using two different derivatization methods.
  • The derivatization method employing the novel click chemistry-based reagent Pyr-NO provides a 10-fold improvement in sensitivity over the alternative derivatization method tested in this study.
To cite this application note: Kennedy, P.D., Rundle, J., and Zhao, T. Use of a novel method of derivatization to improve LC-MS/MS sensitivity of 1,3-dienes. Application Note, Cayman Chemical (2017).
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Use of a Novel Method of Derivatization to Improve LC-MS/MS Sensitivity of 1,3-Dienes<br>
Cayman ChemicalCayman ChemicalCayman Chemical

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