GW 0742

Cayman Chemical Item Number 10006798

(CAS 317318-84-6)

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The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2

1. Sznaidman, M.L., Haffner, C.D., Maloney, P.R., et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity. Bioorg Med Chem Lett 13 1517-1521 (2003).

2. Smith, S.A., Monteith, G.R., Robinson, J.A., et al. Effect of the peroxisome proliferator-activated receptorβ activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res 77 240-249 (2004).

Formal Name [4-​[[[2-​[3-​fluoro-​4-​(trifluoromethyl)phenyl]-​4-​methyl-​5-​thiazolyl]methyl]thio]-​2-​methyl phenoxy]-​acetic acid
CAS Number 317318-84-6
Molecular Formula C21H17F4NO3S2
Formula Weight 471.5
Formulation A crystalline solid
Purity ≥98%
λmax 226, 323 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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GW 0742 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $65.00 $0.00
10 mg $124.00 $0.00
25 mg $293.00 $0.00
50 mg $455.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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