GW 0742
Item № 10006798
CAS № 317318-84-6
Purity ≥98%
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CART TOTAL $0.00
5 mg $65.00 $0.00
10 mg $124.00 $0.00
25 mg $293.00 $0.00
50 mg $455.00 $0.00

Pricing updated 2015-08-28. Prices are subject to change without notice.

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Description

The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2

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Technical Information
Formal Name [4-​[[[2-​[3-​fluoro-​4-​(trifluoromethyl)phenyl]-​4-​methyl-​5-​thiazolyl]methyl]thio]-​2-​methyl phenoxy]-​acetic acid
CAS Number 317318-84-6
Molecular Formula C21H17F4NO3S2
Formula Weight 471.5
Purity ≥98%
Formulation A crystalline solid
λmax 226, 323 nm
SMILES CC1=CC(SCC2=C(C)​N=C(C3=CC=C(C(F)​(F)​F)​C(F)​=C3)​S2)​=CC=C1OCC(O)​=O
InChI Code ​1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)​29-9-19(27)​28)​30-10-18-12(2)​26-20(31-18)​13-3-5-15(16(22)​8-13)​21(23,24)​25/h3-8H,9-10H2,1-2H3,(H,27,28)​
InChI Key HWVNEWGKWRGSRK-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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Download Product Insert 87 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Sznaidman, M.L., Haffner, C.D., Maloney, P.R., et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity. Bioorg Med Chem Lett 13 1517-1521 (2003).

2. Smith, S.A., Monteith, G.R., Robinson, J.A., et al. Effect of the peroxisome proliferator-activated receptorβ activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res 77 240-249 (2004).

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