GW 0742

Cayman Chemical Item Number 10006798

(CAS 317318-84-6)

See more

Description

The transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes.1 GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay.2

1. Sznaidman, M.L., Haffner, C.D., Maloney, P.R., et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity. Bioorg Med Chem Lett 13 1517-1521 (2003).

2. Smith, S.A., Monteith, G.R., Robinson, J.A., et al. Effect of the peroxisome proliferator-activated receptorβ activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res 77 240-249 (2004).

Formal Name [4-​[[[2-​[3-​fluoro-​4-​(trifluoromethyl)phenyl]-​4-​methyl-​5-​thiazolyl]methyl]thio]-​2-​methyl phenoxy]-​acetic acid
CAS Number 317318-84-6
Molecular Formula C21H17F4NO3S2
Formula Weight 471.5
Formulation A crystalline solid
Purity ≥98%
λmax 226, 323 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CC1=CC(SCC2=C(C)​N=C(C3=CC=C(C(F)​(F)​F)​C(F)​=C3)​S2)​=CC=C1OCC(O)​=O
InCHI Code
Copy InCHI code to clipboard
​1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)​29-9-19(27)​28)​30-10-18-12(2)​26-20(31-18)​13-3-5-15(16(22)​8-13)​21(23,24)​25/h3-8H,9-10H2,1-2H3,(H,27,28)​
InCHI Key
Copy InCHI key to clipboard
HWVNEWGKWRGSRK-UHFFFAOYSA-N

Download free InCHI Key generation software

GW 0742 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $79.00 $0.00
10 mg $150.00 $0.00
25 mg $356.00 $0.00
50 mg $632.00 $0.00
Bulk Contact
Cart Total $0.00

Bulk Inquiry Form:

Thank you for requesting a bulk size for this product.










X

Enter number, size, and select unit. Example: 2 x 500 mg




Please indicate any analytical testing requirements, special handling, packaging, or delivery requirements.

Pricing updated 2015-04-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

GW 9578
PPAR (human) Reporter Assays Panel
PPARδ (human recombinant)
PPARδ (human) Reporter Assay Kit
PPARδ (mouse) Reporter Assay Kit
PPARδ Polyclonal Antibody
PPARδ (rat) Reporter Assay Kit
PPARδ Transcription Factor Assay Kit
Show all 8 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...

Lost password?