15-keto Prostaglandin E2 Lipid Maps MS Standard

Cayman Chemical Item Number 10007215

15-keto PGE2 (CAS 26441-05-4)

15-keto Prostaglandin E2 Lipid Maps MS Standard (CAS 26441-05-4)

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Description

15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH.1,2 In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).3

1 Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2 Mak, O.T., Liu, Y., and Tai, H. Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. Biochim Biophys Acta 1035 190-196 (1990).

3 Nishigaki, N., Negishi, M., and Ichikawa, A. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 50 1031-1037 (1996).

Synonyms
  • 15-keto PGE2
Formal Name 9,​15-​dioxo-​11α-​hydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 26441-05-4
Molecular Formula C20H30O5
Formula Weight 350.5
Formulation A crystalline solid
Purity >99%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(=O)​\C=C/[C@H]​1C(O)​CC(=O)​C1C/C=C\CCCC(=O)​O

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Size Price Quantity Subtotal
1 mg $119.00 $0.00
5 mg $536.00 $0.00
10 mg $952.00 $0.00
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Pricing updated 2014-04-19. Prices are subject to change without notice.

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Related Products

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