Prostaglandin F Ethanolamide Lipid Maps MS Standard

Cayman Chemical Item Number 10007222

Dinoprost Ethanolamide; PGF-EA (CAS 353787-70-9)

See more

Description

Prostaglandin F ethanolamide (PGF-EA) is produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.1 AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.2,3 PGF-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.4

1. Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2. Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

4. Woodward, D.F., Tang-Liu, D.D., Madhu, C., et al. Prostaglandin F (PGF) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 27 (2000).

Synonyms
  • Dinoprost Ethanolamide
  • PGF-EA
Formal Name N-​(2-​hydroxyethyl)-​9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​amide
CAS Number 353787-70-9
Molecular Formula C22H39NO5
Formula Weight 397.5
Formulation A solution in ethanol
Purity >99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCCC(O)​/C=C/[C@H]​1C(O)​CC(O)​C1C/C=C\CCCC(=O)​NCCO

Download free InCHI Key generation software

Size Price Quantity Subtotal
1 mg $68.00 $0.00
5 mg $306.00 $0.00
10 mg $544.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Arachidonic Acid
Arachidonoyl Ethanolamide
Prostaglandin D2 Ethanolamide
Prostaglandin E1 Ethanolamide
Prostaglandin E2 Ethanolamide
Prostaglandin F
Prostaglandin F Ethanolamide
Prostaglandin F Ethanolamide-d4
Show all 8 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

JOIN OUR SOCIAL NETWORK!

Please wait...