Prostaglandin F Ethanolamide Lipid Maps MS Standard

Cayman Chemical Item Number 10007222

Dinoprost Ethanolamide; PGF-EA (CAS 353787-70-9)

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Prostaglandin F ethanolamide (PGF-EA) is produced by cyclooxygenase 2 (COX-2) metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.1 AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.2,3 PGF-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.4

1. Bachur, N.R., Masek, K., Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. J Biol Chem 240 1019-1024 (1965).

2. Yu, M., Ives, D., and Ramesha, C.S. Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. J Biol Chem 272 21181-21186 (1997).

3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. J Biol Chem 277(47) 44877-44885 (2002).

4. Woodward, D.F., Tang-Liu, D.D., Madhu, C., et al. Prostaglandin F (PGF) 1-ethanolamide: A pharmacologically unique local hormone biosynthesized from anandamide. 27 (2000).

  • Dinoprost Ethanolamide
  • PGF-EA
Formal Name N-​(2-​hydroxyethyl)-​9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​amide
CAS Number 353787-70-9
Molecular Formula C22H39NO5
Formula Weight 397.5
Formulation A solution in ethanol
Purity >99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $68.00 $0.00
5 mg $306.00 $0.00
10 mg $544.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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