IBMX • Isobutylmethylxanthine; 1-<wbr/>Methyl-<wbr/>3-<wbr/>Isobutylxanthine; NSC 165960 (CAS 28822-58-4) (Inchi key APIXJSLKIYYUKG-UHFFFAOYSA-N) || Cayman Chemical | Supplier
IBMX
Item № 13347
CAS № 28822-58-4
Purity ≥98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
50 mg $16.00 $0.00
100 mg $29.00 $0.00
250 mg $64.00 $0.00
500 mg $96.00 $0.00

Pricing updated 2015-08-29. Prices are subject to change without notice.

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Description
Synonyms
  • Isobutylmethylxanthine
  • 1-Methyl-3-Isobutylxanthine
  • NSC 165960

IBMX is a widely-used non-specific inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX.1 By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors, typically antagonizing the suppressive effects of natural agonists.2

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Technical Information
Formal Name 3,​9-​dihydro-​1-​methyl-​3-​(2-​methylpropyl)-​1H-​purine-​2,​6-​dione
CAS Number 28822-58-4
Synonyms
  • Isobutylmethylxanthine
  • 1-Methyl-3-Isobutylxanthine
  • NSC 165960
Molecular Formula C10H14N4O2
Formula Weight 222.3
Purity ≥98%
Formulation A crystalline solid
SMILES CC(C)​CN(C1=C2NC=N1)​C(N(C)​C2=O)​=O
InChI Code ​1S/C10H14N4O2/c1-6(2)​4-14-8-7(11-5-12-8)​9(15)​13(3)​10(14)​16/h5-6H,4H2,1-3H3,(H,11,12)​
InChI Key APIXJSLKIYYUKG-UHFFFAOYSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 131 Kb PDF

Download Safety Data Sheet (SDS) 29 Kb PDF

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Additional Information

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Inserts
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References & Background Reading
Product Description References

1. Fawcett, L., Baxendale, R., Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 97(7) 3702-3707 (2000).

2. Snyder, S.H., Katims, J.J., Annau, Z., et al. Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci USA 78(5) 3260-3264 (1981).

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