A non-selective COX inhibitor
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Zaltoprofen

Item No. 14662

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-a-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
CAS Number
74711-43-6
Synonyms
  • CN 100
  • Soleton
Molecular Formula
C17H14O3S
Formula Weight
298.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 16 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 11 mg/mlPBS (pH 7.2): Insolulble
λmax
228, 329 nm
SMILES
CC(C(O)=O)C1=CC(CC(C(C=CC=C2)=C2S3)=O)=C3C=C1
InChi Code
InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20)
InChi Key
MUXFZBHBYYYLTH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $95

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    50 mg

    $186

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    100 mg

    $251

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    250 mg

    $464

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    Product Description

    Zaltoprofen is a cyclooxygenase (COX) inhibitor that displays slight preferential inhibition for COX-2 (IC50s = 1.3 and 0.34 μM for COX-1 and COX-2, respectively).1 Independent of COX inhibition, zaltoprofen has also been reported to inhibit bradykinin-induced nociceptive responses by blocking the activation of protein kinase C.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawai, S., Nishida, S., Kato, M., et al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur. J. Pharmacol. 347(1), 87-94 (1998).

    2. Kohno, T. Zaltoprofen inhibits bradykinin-mediated enhancement of glutamate receptor activity in substantia gelatinosa neurons. Anesth. Analg. 113(2), 412-416 (2011).