Rosmarinic Acid

Cayman Chemical Item Number 70900

(CAS 20283-92-5)

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Rosmarinic acid is a naturally-occurring phenolic compound with antioxidant and anti-inflammatory properties. This compound inhibits lipid peroxidation of rat liver microsomes by 90% at a concentration of 25 µg/ml.1 Rosmarinic acid suppresses endotoxin-induced activation of complement and concomitant formation of prostacyclin.2,3 Formation of 5-HETE and LTB4 from human PMNL is inhibited by rosmarinic acid at concentrations of 10-5 to 10-3 M.4

1. Liu, G., Zhang, T., Wang, B., et al. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 43 147-152 (1992).

2. Bult, H., Herman, A.G., and Rampart, M. Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid. Br J Pharmacol 84 317-327 (1985).

3. Rampart, M., Beetens, J.R., Bult, H., et al. Complement-dependent stimulation of prostacyclin biosynthesis: Inhibition by rosmarinic acid. Biochem Pharmacol 35 1397-1400 (1986).

4. Kimura, Y., Okuda, H., Okuda, T., et al. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. J Nat Prod 50 392-399 (1987).

Formal Name (R)-​α-​[[3-​(3,​4-​dihydroxyphenyl)-​1-​oxo-​2E-​propenyl]oxy]-​3,​4-​dihydroxy-​benzenepropanoic acid
CAS Number 20283-92-5
Molecular Formula C18H16O8
Formula Weight 360.3
Formulation A crystalline solid
Purity >98%
λmax 221, 291, 332 nm
Stability 1 year
Storage Room temperature
Shipping Room temperature in continental US; may vary elsewhere
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Rosmarinic Acid is available in the following screening library:

Size Price Quantity Subtotal
5 mg $12.00 $0.00
10 mg $23.00 $0.00
50 mg $96.00 $0.00
100 mg $168.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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