Item № 75860
CAS № 153190-29-5
Purity ≥99%
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50 mg $55.00 $0.00
100 mg $88.00 $0.00
250 mg $206.00 $0.00

Pricing updated 2015-10-06. Prices are subject to change without notice.

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  • Methylated Tirilazad

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.1,2,3,4

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Technical Information
Formal Name 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-pregna-1,4,9(11)-triene-3,20-dione maleate salt
CAS Number 153190-29-5
  • Methylated Tirilazad
Molecular Formula C37H50N6O2 • C4H4O4
Formula Weight 726.9
Purity ≥99%
Formulation A crystalline solid
λmax 237, 287 nm
SMILES C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=CC(N5CCCC5)=NC(N6CCCC6)=N4)CC3)=O)([H])[C@](C7=CC1)([H])CCC([C@]7(C)C=C8)=CC8=O.OC(/C=C\C(O)=O)=O
InChI Code 1S/C37H50N6O2.C4H4O4/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-40)34-24-33(41-15-3-4-16-41)38-35(39-34)43-17-5-6-18-43;5-3(6)1-2-4(7)8/h11-13,23-24,28-29,31H,3-10,14-22,25H2,1-2H3;1-2H,(H,5,6

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 1 year
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Download Product Insert 126 Kb PDF

Download Safety Data Sheet (SDS) 22 Kb PDF

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References & Background Reading
Product Description References

1. Ishizaki, N., Zhu, Y., Zhang, S., et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation 63 202-208 (1997).

2. Palma-Vargas, J.M., Toledo, A.H., García-Criado, F.J., et al. 21-Aminosteroids block neutrophil infiltration and provide liver protection independent of nitrite/nitrate levels. J Surg Res 66 131-137 (1996).

3. Perna, A.M., Liguori, P., Bonacchi, M., et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res 34 25-31 (1996).

4. Shoskes, D.A., Xie, Y., and Gonzalez-Cadavid, N.F. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat. Implications for renal transplantation. Transplantation 63 495-500 (1997).

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