An antioxidant that prevents iron-dependent lipid peroxidation
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

U-74389G

Item No. 75860

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]-pregna-1,4,9(11)-triene-3,20-dione maleate salt
CAS Number
153190-29-5
Synonyms
  • Methylated Tirilazad
Molecular Formula
C37H50N6O2 • C4H4O4
Formula Weight
726.9
Purity
≥99%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 36.3 mg/mlDMSO: 35.3 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.05 mg/mlEthanol: 1.36 mg/ml
λmax
237, 287 nm
SMILES
C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=CC(N5CCCC5)=NC(N6CCCC6)=N4)CC3)=O)([H])[C@](C7=CC1)([H])CCC([C@]7(C)C=C8)=CC8=O.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C37H50N6O2.C4H4O4/c1-36-13-11-27(44)23-26(36)7-8-28-29-9-10-31(37(29,2)14-12-30(28)36)32(45)25-40-19-21-42(22-20-40)34-24-33(41-15-3-4-16-41)38-35(39-34)43-17-5-6-18-43;5-3(6)1-2-4(7)8/h11-13,23-24,28-29,31H,3-10,14-22,25H2,1-2H3;1-2H,(H,5,6
InChi Key
ABCSSKWSUJMJCP-WQDFMEOSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $80

    Add

    100 mg

    $127

    Add

    250 mg

    $293

    Add
    Product Description

    U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishizaki, N., Zhu, Y., Zhang, S., et al. Comparison of various lazaroid compounds for protection against ischemic liver injury. Transplantation 63(2), 202-208 (1997).

    2. Palma-Vargas, J.M., Toledo, A.H., García-Criado, F.J., et al. 21-Aminosteroids block neutrophil infiltration and provide liver protection independent of nitrite/nitrate levels. J. Surg. Res. 66(2), 131-137 (1996).

    3. Perna, A.M., Liguori, P., Bonacchi, M., et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol. Res. 34(1-2), 25-31 (1996).

    4. Shoskes, D.A., Xie, Y., and Gonzalez-Cadavid, N.F. Nitric oxide synthase activity in renal ischemia-reperfusion injury in the rat. Implications for renal transplantation. Transplantation 63(4), 495-500 (1997).