Literature & Media

A Recombinant SARS-CoV-2 Neutralizing Antibody Blocks the Spike RBD-ACE2 Interaction; A Biophysical Characterization Using SPR

Scientific posters

Cayman Chemical, in collaboration with Thermo Fisher Scientific, investigated the ability of a SARS-CoV-2 neutralizing antibody (nAb) to block the spike S1 RBD-ACE2 interaction using cryoEM and SPR. This poster presentation focuses on the production and characterization of recombinant proteins hACE2 and S1 RBD wild-type and Alpha and Beta variants, an evaluation of the binding kinetics and affinity measurements for the nAb towards S1 RBD in the presence of ACE2, and how the knowledge presented in this study will help design more potent recombinant antibodies and vaccines against new SARS-CoV-2 variants.

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To cite this poster: Assar, Z., Muzzarelli, K., Ho, W., Hines, J., Bickel, J., Drulyte, I., and Pisano, M.
A Recombinant SARS-CoV-2 Neutralizing Antibody Blocks the Spike RBD-ACE2 Interaction; A Biophysical Characterization Using SPR. Poster presented at the 19th Annual Discovery on Target Conference; September 27 – 30, 2021; Boston, MA.


Cayman ChemicalCayman ChemicalCayman Chemical

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