Literature & Media

A Novel Series of Selective Agonists Evaluated against Rattus Norvegicus EP4 Receptor

Application notes

  • Cayman scientists deliver KMN-159, a novel, selective EP4 receptor agonist with lower entropic costs of binding and increased affinity than other known agonists.​
  • ​KMN-159 was identified from a series of stereoisomerically pure EP4 receptor-selective agonists evaluated by docking onto a rat EP4 receptor model using AutoDock and Schrödinger.
  • Continued development of novel, selective EP4 agonists will further elucidate the role of this receptor and aid in the identification of novel therapeutics for bone growth, cardiovascular function, and disease.​
To cite this application note: Holt, M.C., Sidhu, R., Ho, B., et al. A novel series of selective agonists evaluated against Rattus norvegicus EP4 receptor. Application Note, Cayman Chemical (2017).
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A Novel Series of Selective Agonists Evaluated against <em>Rattus Norvegicus</em> EP<sub>4</sub> Receptor
Cayman ChemicalCayman ChemicalCayman Chemical

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