New synthetic cannabinoids continue to emerge in the recreational drug supply following the class-wide ban implemented by China in July 2021. This NPS Discovery Monograph documents the newly identified synthetic cannabinoid ADB-5'Br-BINACA (ADB-5'Br-BUTINACA) containing a brominated indazole core, confirmed using Cayman's reference standard. To avoid confusion with tail substituents, Cayman and the CFSRE have developed a revised naming convention for new synthetic cannabinoids containing core substituents, denoted by a prime (‘) designation placed in the middle of the name.