Octadecanoids, oxylipins derived from linoleic or linolenic acids, are being increasingly recognized as having important effects in biological responses. Here we show how authentic standards of several isomeric octadecanoids facilitate the establishment of LC–MS/MS method for the detection and quantitation of epoxyoctadecadienoic acids (EpODEs) and dihydroxyoctadecadienoic acids (DiHODEs) in rat plasma.

To cite this application note: DeLoy, S., Dittmer, J., LaGory, D., et al. ​​Analysis of Complex Mixtures of Octadecanoid Isomers by LC–MS/MS. Application Note, Cayman Chemical (2025).