The basic benzodiazepine scaffold has been modified to create a broad class of compounds differing in potency, how quickly they are absorbed into the body, and what they are used to treat. Cayman's scientists have developed this laboratory guide for toxicologists to help demystify drug screening results by providing likely metabolites that should be encountered during the metabolism of several major classes of benzodiazepines.

In this guide for benzodiazepine metabolism we review:

• The Phase I and Phase II Metabolite Biotransformation Pathway
  
• Likely Metabolites of 7-Halogenated-, 7-Nitro-, Thieno-, and Triazolo- Classes of Benzodiazepines
  
• Half-Life of Common Benzodiazepines
  
• Benzodiazepine Prodrugs