Literature & Media

Calcium-dependent Hit Identification for PAD4 Inhibitors with FDA-approved and Fragment-based Library Approaches

Scientific posters

In this high-throughput screening (HTS) program, we ran screens under two different conditions in order to assess the calcium sensitivity of PAD4 inhibitor fragments and compounds. The resultant assays maintained requirements for high-throughput screening in a 384-well format (Z’ > 0.5) and in comparison allowed for identification of calcium-sensitive and -insensitive compounds for further development. 

Do you have a question or comment for the presenter? Let us know.

To cite this poster: Foss, M., Abdel-Haq, R., Muzzareli, K., et al. Calcium-dependent hit identification for PAD4 inhibitors with FDA-approved and fragment-based library approaches. Poster presented at: 19th Annual Drug Discovery Chemistry Conference; April 1-4, 2024. San Diego, CA.
Download Copy (PDF)
Calcium-dependent Hit Identification for PAD4 Inhibitors with FDA-approved and Fragment-based Library Approaches<br>
Cayman ChemicalCayman ChemicalCayman Chemical

Receive Our News & Literature Directly to Your Inbox!

Log in or register to subscribe to our email list. You will receive emails packed with new products and content that match your research interests. We only email once a week and you can unsubscribe at any time.