Literature & Media

Δ9-THC, Δ10-THC, and Δ6a,10a-THC: Cayman NPS Metabolism Monograph, Issue 3

Monographs

The goal of this monograph is to identify the probable metabolites of the newly emerging semi-synthetic cannabinoids Δ10-THC and Δ6a,10a-THC using human liver microsomes (HLMs) and high-resolution mass spectrometry. The metabolism of Δ9-THC with HLMs was also investigated to provide forensic toxicologists a comparative understanding of the key fragments needed for identification.

This monograph was updated on April 18th, 2025, to provide clarification on the interpretation of the (6aR,9R)-Δ10-THC metabolite at R.T. 14.16 minutes in Figure 8. 

To cite this monograph: Bassman, J.R., Layle, N.K., Gregerson, M.C., et al. Δ9-THC, Δ10-THC, and Δ6a,10a-THC. Cayman NPS Metabolism Monograph Issue 3 (2025). 

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<p>Δ<sup>9</sup>-THC, Δ<sup>10</sup>-THC, and Δ<sup>6a,10a</sup>-THC&#58; Cayman NPS Metabolism Monograph, Issue 3<br></p>
Cayman ChemicalCayman ChemicalCayman Chemical

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