​Many studies have linked extracellular vesicles (EVs) to disease progression. For example, EVs from diabetic and obese mice can induce insulin resistance while EVs from healthy mice can reverse these effects. EVs are lipid bilayer nanoparticles released from cells by a variety of mechanisms. These particles are known to contain a variety of cargo, such as lipids, proteins, nucleic acids, and other metabolites that are believed to be responsible for their cell signaling activity. 

In this study, we have performed untargeted lipidomics analysis on isolated plasma EVs from healthy and diet-induced obese, prediabetic C57BL6/J mice to study potential differences in their lipid profiles.

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To cite this poster: Kennedy, P.D., Saepoo, B., Palagama, D.S.W., et al. Characterization of Extracellular Vesicle Lipids in Pre-Diabetic Mice. Poster presented at: 8th Lipidomics Forum: ILS Annual Conference; August 27-30, 2023; Vienna, Austria