Hydrogenation of tetrahydrocannabinols (Δ⁸- or Δ⁹-THC) leads to formation of a mixture of hexahydrocannabinols (HHCs) comprised of the 9(S)- and 9(R)-HHC diastereomers. These compounds retain some psychoactivity but avoid classification as THCs as well as any THC-related regulations. Separation of the HHC diastereomers is possible by TLC, HPLC, and GC-MS, but identity cannot be inferred without verified reference standards. Full NMR characterization of the two HHC diastereomers is necessary for confirmation and has not previously been described.

This poster provides information that can aid in the correct identification and differentiation of the products resulting from hydrogenation of Δ⁸- and/or Δ⁹-THC

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To cite this poster: Stothard, A., Layle, N., Martin, M., et al. Characterization of Hexahydrocannabinol Diastereomers by NMR, HPLC, GC-MS, and TLC.