Lipids are key molecules in maintaining cellular membranes, in energy storage, cellular signaling, and many other biological processes. Mass spectrometry has become the gold standard for analyzing lipids and understanding their roles in health and disease, and well-characterized reference materials increase confidence in lipid quantitative data by validating the analytical methods employed.

The objective of this study is to characterize a preparation of human plasma as a reference for the analysis of a wide variety of lipids, using both targeted and untargeted LC-MS-based methods which are validated by comparison with the NIST SRM 1950 Metabolites in Human Plasma material.

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To cite this poster: Kwiatkowski, M.J., Goodwin, S.K., DeLoy, S.L., et al. Characterization of human plasma as a reference material for lipid analysis using LC-MS. Poster presented at: 73^rd Conference on Mass Spectrometry and Allied Topics; June 1-5, 2025; Baltimore, MD.