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Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of “nitazene” 2-benzylbenzimidazole synthetic opioids

Scientific posters


The nitazene synthetic opioid class has high potential to activate µ-opioid receptor (MOR) and may pose an imminent threat to any user. This collaborative study between Ghent University and Cayman Chemical investigated the opioid activity of several nitazenes. In doing so, we discovered the unexpected high potency of one of the nitazene metabolites, rivalling the potency of etonitazene and exceeding that of isotonitazene itself.

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To cite this poster: Vandeputte, M.M., Uytfanghe, K.V., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of “nitazene” 2-benzylbenzimidazole synthetic opioids. Poster presented at: Society of Forensic Toxicologists Meeting; September 26-30, 2021.
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Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of “nitazene” 2-benzylbenzimidazole synthetic opioids<br>
Cayman ChemicalCayman ChemicalCayman Chemical

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