Literature & Media

Examining the FP receptor-triggered CREB activation in cell-based assays

Scientific posters

The PGF2α receptor (FP) was initially characterized as a Gq-coupled receptor, which leads to an increase in inositol triphosphate/diacylglycerol, intracellular calcium mobilization, and protein kinase C (PKC) activation. Interestingly, PGF2α has also been suggested to induce CREB- regulated genes in human amniotic fibroblasts and tracheobronchial epithelial cells through PKC activity. The activation of CREB by the FP receptor has been reproduced in this study by co-transfecting the FP receptor with a CRE-SEAP reporter into HEK293T cells using reverse transfection.

To cite this poster: Ho, C.S., Patel, C., Saepoo, B., et al. Examining the FP receptor-triggered CREB activation in cell-based assays. Poster presented at: 2018 ASCB|EMBO Annual Meeting; December 8-12, 2018; San Diego, CA.
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Examining the FP receptor-triggered CREB activation in cell-based assays<br>
Cayman ChemicalCayman ChemicalCayman Chemical

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