Literature & Media

GC Separation for Identification of iso-THC Contaminants and Accurate Quantification of Δ8 -THC and Δ9-THC in Cannabis Samples

Application notes

Key Features

  • Synthetic conversion of cannabidiol (CBD) to the tetrahydrocannabinols (THCs) Δ9-THC and Δ8 -THC produces measurable quantities of the iso-THC products Δ8-iso-THC and Δ4(8)-iso-THC.
  • Co-elution of THCs and iso-THCs makes C18 reversed phase-HPLC (RP-HPLC) methods unsuitable for the quantification of THCs. Quantities of THCs are distorted if the testing methods are unable to resolve the iso-THCs in analyzed samples.
  • Gas chromatography (GC) offers a reliable and robust method for quantification of Δ9-THC, Δ8-THC, Δ8-iso-THC, and Δ4(8)-iso-THC. Additionally, this method represents a method for identifying THC derived from CBD conversion.

To cite this application note: Williams, J.B., Liu, J., and Hering, K.W. GC separation for identification of iso-THC contaminants and accurate quantification of Δ8-THC and Δ9-THC in Cannabis samples. Application Note, Cayman Chemical (2023).

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GC Separation for Identification of <em>iso</em>-THC Contaminants and Accurate Quantification of Δ<sup>8</sup> -THC and Δ<sup>9</sup>-THC in <em>Cannabis</em> Samples<br>
Cayman ChemicalCayman ChemicalCayman Chemical

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