Literature & Media

​High-Throughput Flow Cytometric Screening of a Kinase Inhibitor Library for Apoptosis Induction

Application notes

​Key Information

  • Cayman’s multiparametric Early Apoptosis Detection Assay Kit used with Miltenyi Biotec’s MACSQuant® X Flow Cytometer creates a powerful, efficient, and exquisitely detailed screening tool.
  • Using this approach to screen a library of kinase inhibitors for cytotoxicity, apoptosis inducers were distinguished from necrosis-causing or mitochondrial-uncoupling compounds.
  • This simple approach can be adapted to many other probes for cellular function to help determine the effects of potential therapeutic compounds during the drug development process.


To cite this application note: Rumble, J.M., Hoffman, D.L. High-Throughput Flow Cytometric Screening of a Kinase Inhibitor Library for Apoptosis Induction. Application Note, Cayman Chemical (2020).

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<p>​High-Throughput Flow Cytometric Screening of a Kinase Inhibitor Library for Apoptosis Induction<br></p>
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