Literature & Media

Discovery of Potential Soluble Epoxide Hydrolase Inhibitors Using a High-throughput Screening Assay on a 235 Compound Library

Application notes

Key Features

  • Soluble epoxide hydrolase (sEH) inhibitors are a promising strategy for the treatment of inflammatory and cardiovascular conditions.
  • We have developed an automated high-throughput screening (HTS) platform to identify small molecule inhibitors that enables testing of a large number of compounds in days instead of weeks using minimal sample volumes.
  • We screened all 235 compounds in Cayman’s Anti-Inflammatory Screening Library and identified 36 compounds as potential sEH inhibitors using this approach.
  • This HTS platform accelerates drug discovery. It can be adapted to many other enzyme activity assays and performed using Cayman or client-provided compound libraries.

To cite this application note: Contract Services Screening Group. Discovery of Potential Soluble Epoxide Hydrolase Inhibitors Using a High-throughput Screening Assay on a 235 Compound Library. Application Note, Cayman Chemical (2022).

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Discovery of Potential Soluble Epoxide Hydrolase Inhibitors Using a High-throughput Screening Assay on a 235 Compound Library<br>
Cayman ChemicalCayman ChemicalCayman Chemical

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