LSD is the classic member of psychedelic lysergamides. Structural modifications to three main regions of the LSD scaffold have resulted in the emergence of new lysergamides entering the novel psychoactive substances (NPS) market.

To support toxicologists and forensic chemists tasked with the identification of these drugs, this poster describes the common naming conventions used for lysergamides and presents common lysergamide substitutions, fragments, and tips for mass spectrometry interpretation to help the forensic community decipher the structure of new lysergamides.

In this guide for lysergamide identification and naming, we review:

• Common lysergamide substitutions
  
• Common lysergamide MS fragments
• Proposed mechanism for some fragments
• Mass spectrum of 1P-LSD and tips for interpretation

Review the list of primary resources used to collate this guide here.

To cite this poster: Watson-Gooden, C., Pierzynski, H., Iula, D.M., and Hering, K.W. Laboratory Guide for Lysergamide Identification and Naming. September 2023.