Literature & Media

Mitochondrial Fuel Flexibility Assessment in a Tumor-Relevant Model

Application notes

The tumor microenvironment (TME) consists of low [O2], low pH, and high concentrations of fatty acids. The high amounts of fatty acids are produced by cancer cells as a metabolic by-product. Myeloid-derived suppressor cells (MDSCs) thrive on these high fatty acid concentrations via fatty acid oxidation (FAO). Under these conditions, they support tumor growth by suppressing T cells that would normally attack the tumor.

Highlights:

  • Examines metabolic flexibility of cancer cells and human MDSCs in a simulated tumor microenvironment
  • Demonstrates the power of combining Seahorse XFe96 technology with manipulation of the major mitochondrial fuel pathways
To cite this application note: Hoffman, D.L. Mitochondrial fuel flexibility assessment in a tumor-relevant model. BioTechniques67(3), 139-140 (2019).
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Mitochondrial Fuel Flexibility Assessment in a Tumor-Relevant Model
Cayman ChemicalCayman ChemicalCayman Chemical

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