​In July 2021, China banned several common synthetic cannabinoid core scaffolds to control the manufacturing and trafficking of these substances. This NPS Discovery Monograph documents the first report of CHO-4'Me-5'Br-FUBOXPYRA, a novel synthetic cannabinoid possessing an alternative 2-oxopyridine core scaffold. Cayman and the CFSRE established the “OXPYRA” systematic naming convention to be structurally informative and parallel existing synthetic cannabinoid NPS nomenclature, such as the OXIZID and IATA class.