​Opioid-related fatalities involving synthetic narcotics have reached unprecedented levels. This study evaluated the respiratory depressant effects of seven fentanyl analogs that have either emerged in the recreational drug marketplace or been identified in toxicological analyses following fatal or non-fatal intoxications and for which their effects on ventilation had not been previously characterized. These results establish that the respiratory depressant effects of these fentanyl analogs are at least in part mediated by opioid receptors.

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To cite this poster: Varshneya, N.B., Hassanien, S.H., Holt, M.C., et al. Respiratory depressant effects of fentanyl analogs. Poster presented at: American Society for Pharmacology and Experimental Therapeutics Virtual Meeting; April 27-30, 2021.