Literature & Media

​Seropositivity Testing for SARS-CoV-2 Neutralizing Antibodies

Application notes

​Key Features

  • The detection of SARS-CoV-2 neutralizing antibodies offers important information for evaluating immune responses to COVID-19. It has multiple applications such as studies of herd immunity and vaccine development among others.
  • Cayman’s SARS-CoV-2 Neutralizing Antibody Detection ELISA Kit functions as both a simple, qualitative indicator of positive or negative samples and as a semi-quantitative indicator of seropositivity.
  • Disease-free positive and negative plasma controls are supplied to confirm the assay is performing as expected.
  • Approximating concentrations of neutralizing antibody found in positive samples is achieved using a neutralizing antibody as a reference standard.
  • The format of our ELISA (in which neutralizing antibodies must recognize the SARS-CoV-2 spike receptor binding domain to inhibit ACE2 binding) provides an efficient and effective screening tool for determining functional antibody neutralization capabilities.
  • The semi-quantitative design is the first of its kind for SARS-CoV-2 seropositivity testing and provides a consistent reference point for neutralizing antibody levels not readily available with standard serological assays.

To cite this application note: Tew, D.J., Blaylock, J.B., and Metcalfe, K.C. Seropositivity Testing for SARS-CoV-2 Neutralizing Antibodies. Application Note, Cayman Chemical (2020).

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<p>​Seropositivity Testing for SARS-CoV-2 Neutralizing Antibodies<br></p>
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