The current wave of so-called ‘semi-synthetic cannabinoids’ are defined as molecules that are not fully synthetic, as in JWH-018 or AB-FUBINACA, nor are they naturally occurring, as in Δ⁹-THC. This new class of ‘semi-synthetic’ NPS (Novel Psychoactive Substances) are structurally phytocannabinoid-like in composition and are similar to Δ⁹-THC. Analytical labs, clinicians, and policy administrators have always struggled to keep pace with the ever-changing synthetic cannabinoid landscape while keeping detection methods and policies current with the latest molecules-of-the-moment.

Jeffrey Williams presents a summary of the current wave of NPS called ‘semi-synthetic cannabinoids’ which are complicating the NPS scene.

Presented as part of the CFSRE's 2025 Current Trends in Forensic Toxicology Symposium.

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