The emergence of previously unencountered novel psychoactive substances (NPS) in adulterated tablets, vape cartridges, and other consumer-marketed products continues to push forensic chemists, forensic toxicologists, emergency medical responders, and regulatory agencies into unchartered territory. Adding complexity to this evolving landscape is the recent discovery of semi-synthetic compounds in consumer products — substances not typically found in nature or present in quantities that suggest synthetic laboratory production.

Donna Iula summarizes the novel substances of greatest concern across classes such as synthetic opioids, benzodiazepines, stimulants, and synthetic cannabinoids including the concerning rise of semi-synthetic opioid NPS derived from Kratom, which are extremely potent.

Presented as part of the CFSRE's 2026 Current Trends in Seized Drug Analysis Symposium.

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