Cayman Chemical, in collaboration with PinPoint Testing, LLC and Biotage, has introduced the ToxBox^® THC/THC Metabolite Pack, an all-inclusive tool to detect THC, the primary active constituent in Cannabis, and its main metabolites. ToxBox^®, a proprietary brand of products by PinPoint Testing, is a high-throughput solution for detecting multiple analytes in biological samples. The ToxBox^® THC/THC Metabolite Pack contains all necessary plates and reagents for sample preparation and detection of Δ⁹-THC, (±)-11-nor-9-carboxy-Δ⁹-THC, and (±)-11-hydroxy-Δ⁹-THC. This provides a new approach to streamlined Cannabis testing by LC-MS/MS with the sensitivity required by forensic and toxicology labs.

The ToxBox^® THC/THC Metabolite Pack is designed to be used in a specialized 48-well plate system as a three-step workflow process for increased efficiency and sample throughput. Each pack is supplied with pre-mixed analytical standards in a plate-based format containing a set of calibrators, quality control materials, and internal standards dissolved in a proprietary solution. This system also includes an ISOLUTE^® SLE+ supported liquid extraction plate to enable high analyte recovery from biological fluids and blank plates for easy sample handling. Compared to dilute-and-shoot methods, this three-step well-plate format reduces sample preparation labor and obviates potential laboratory dilution and sample preparation errors. Ample well space is available for samples to be run in duplicate or triplicate (depending on sample number) to detect THC levels down to per se statute limits (1.0-5.0 ng). The product contains Certified Reference Materials from ISO/IEC 17025:2005 and ISO Guide 34:2009 labs and can be implemented in existing laboratory methods for quantitation.

The ToxBox^® THC/THC Metabolite Pack is available through Cayman Chemical. PinPoint Testing offers consulting to accelerate analytical method development, validation, and implementation as well as custom ToxBox^® products.

To learn more about PinPoint Testing and ToxBox®, view the video.

PinPoint Testing, LLC is a partnership composed of leading scientists that provide forensic, public health, and medical labs with advice and reagents to detect drugs of abuse in critical blood and urine samples. The expertise of PinPoint Testing, LLC spans organic and medicinal chemistry, pharmacology, toxicology, pharmacokinetics, forensic science, and legal testimony. For the past five years, the partners and associates of PinPoint Testing, LLC have stayed on the forefront of devising methods to identify designer drugs in order to help clinical and forensic laboratories meet their missions.

Biotage offers efficient separation technologies from analysis to industrial scale and high quality solutions for analytical chemistry from research to commercial analysis laboratories. Biotage’s products are used by government authorities, academic institutions, pharmaceutical and food companies, among others. The company is headquartered in Uppsala and has offices in the US, UK, China, Japan and South Korea. Biotage is listed on the NASDAQ OMX Nordic.