For immunochemical detection of optineurin
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Optineurin (INT) Polyclonal Antibody

Item No. 100002

Product Insert (PDF)
Technical Information
Synonyms
  • FIP-2
  • NRP
Immunogen
Synthetic peptide from the internal region of human optineurin
Formulation (Request formulation change)
500 µl of Peptide affinity-purified polyclonal antibody
Storage Buffer
TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide
Host
Rabbit
Applications
IHC and WB; other applications not tested
Species Reactivity
(+) Human(-) Murine(-) Rat(-) Porcine
UniProt Accession №
Q96CV9
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.

    WARNING This product is not for human or veterinary use.